Common complications of Campylobacter Jejuni infection?

Common complications of Campylobacter Jejuni infection?

• A. Guillain Barré syndrome
• B. Reactive arthritis
• C. Reactive arthritis, Guillain Barré syndrome
• D. Meningitis

Answer: (C)

Campylobacter jejuni infection is well known for triggering autoimmune reactions that can follow the acute illness. The two most classic post-infectious complications are Guillain-Barré syndrome, a demyelinating peripheral neuropathy that can cause ascending weakness, and reactive arthritis, an inflammatory joint condition that can occur weeks after the GI illness. Guillain-Barré is thought to arise from molecular mimicry, where antibodies against Campylobacter antigens cross-react with nerve components such as gangliosides, leading to nerve damage. Reactive arthritis occurs as part of a broader spondyloarthropathy spectrum and is associated with immune responses after infection, with HLA-B27 sometimes playing a role. Meningitis is not a common complication of Campylobacter infection, though very rare cases can occur in specific circumstances. Therefore, the two most typical complications are Guillain-Barré syndrome and reactive arthritis, making the combined option the best choice.

Campylobacter jejuni infection is well known for triggering autoimmune reactions that can follow the acute illness. The two most classic post-infectious complications are Guillain-Barré syndrome, a demyelinating peripheral neuropathy that can cause ascending weakness, and reactive arthritis, an inflammatory joint condition that can occur weeks after the GI illness. Guillain-Barré is thought to arise from molecular mimicry, where antibodies against Campylobacter antigens cross-react with nerve components such as gangliosides, leading to nerve damage. Reactive arthritis occurs as part of a broader spondyloarthropathy spectrum and is associated with immune responses after infection, with HLA-B27 sometimes playing a role. Meningitis is not a common complication of Campylobacter infection, though very rare cases can occur in specific circumstances. Therefore, the two most typical complications are Guillain-Barré syndrome and reactive arthritis, making the combined option the best choice.