UF CPP Infectious Diseases Practice Test 2026 – The Comprehensive All-in-One Guide to Exam Success!

Janeway lesions are painless, hemorrhagic skin lesions that arise from septic emboli in acute infective endocarditis. They characteristically appear on the palms and soles, reflecting embolic seeding of the dermis in those areas. This non-tender presentation helps distinguish them from Osler nodes, which are painful nodules on finger and toe pads caused by immune complex deposition. Locations like the eyelids, trunk, or mucous membranes are not typical sites for these lesions, making the palms and soles the classic and most associated location.